MOLECULAR UNDERPINNINGS OF Excitability
The national BRAIN Initiative has set out to map the circuits of the brain to understand how neuronal connections give rise to cognition and behavior. Critical to this initiative’s success is understanding how the flow of electrical information is modulated between neurons in this circuit. Our research explores the molecular mechanisms that control excitability in the neuron. We pursue this goal by devising optical strategies to quantitatively measure neuronal function using a combination of custom optics, genetically encoded indicators, biochemistry, moxy and grit.
